UWA Centre for Comparative Analysis of Biomolecular Networks (CABiN)
Why study biomolecular networks?
We live in large communities, but self-censor by a circle of friends (social network), set travel routes (spatial network) and the times we work, rest and play (temporal network). The power of networks is not only how they structure behaviour, but how they can distribute information and alter a community's future. Cells are also communities, ordered through networks of molecules (genes, transcripts, proteins and metabolites). Analysis of biomolecular networks will enhance our efforts to influence cell function.
Why compare these networks?
The rapid accumulation of network-related data from many species provides unprecedented opportunities to study the function and evolution of biological systems. Evolution acts on these networks as function units, rather than on single molecules. The basic goal of network comparison is to uncover identical or similar sub-networks by mapping changes in one network to another. Such analysis can reveal important biological links, and explain how networks evolved, how natural variation alters networks, and how engineering of networks can provide novel biological outcomes.
What can CABiN contribute?
Located at the University of Western Australia, CABiN offers a pathway for scientists to perform collaborative research across discipline divides using cutting edge analytical tools to provide molecular insight into diverse biological questions. The ultimate goal is to provide more proximate solutions to broader questions that demand molecular insights. CABiN focuses on protein and metabolite analysis by mass spectrometry. Data visualisation shows the landscape of networks and aids discovery of novel biological insights.